Introduction

BioClear New is a xylene substitute used as a clearing agent. Clearing agents are completely miscible with alcohol and paraffin which makes them an ideal intermedium between alcohol and embedding paraffin (BioWax), as well as alcohol and section mounting agent. Beside xylene, the standard clearing agent, aliphatic hydrocarbon-based xylene substitutes are more and more frequently used (such as BioClear New); they are weakly reactive and low toxic. They are not irritable and do not cause hypersensibility. Results of clearing using them are comparable to the results of using xylene. BioClear New can be used with every tissue processing device and automated slide stainers. Adequately dehydrated and cleared tissue sample becomes transparent and appropriate for microscopic analysis. Using BioClear New will not make tissue samples too solid, and it is characterized by quick tissue infiltration and efficient removal of fatty tissues.